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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
15/04/2021 |
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Actualizado : |
15/04/2021 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
COSTA, D.; LÉVESQUE, S.; KUMAR, N.; FRESIA, P.; FERRÉS, I.; LAWLEY, T. D.; IRAOLA, G. |
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Afiliación : |
DANIELA COSTA, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; Sección Genética Evolutiva, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay; SIMON LÉVESQUE, Laboratoire de Santé Publique du Québec, Quebec City, Canada; NITIN KUMAR, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; PABLO FRESIA, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; IGNACIO FERRÉS, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; TREVOR D. LAWLEY, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; GREGORIO IRAOLA, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Center for Integrative Biology, Universidad Mayor, Santiago de Chile, Chile. |
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Título : |
Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts. |
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Fecha de publicación : |
2021 |
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Fuente / Imprenta : |
Scientific Reports, 2021, Volume 11, Issue 1, Article number 3431. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-021-82993-9 |
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ISSN : |
2045-2322 |
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DOI : |
10.1038/s41598-021-82993-9 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 12 February 2018; Accepted 24 January 2021; Published 09 February 2021. |
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Contenido : |
ABSTRACT.
Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the underlying mechanism driving its diversification. Concordantly, both subspecies present distinct patterns of gene families involved in genome plasticity and DNA repair like CRISPR-associated proteins and restriction-modification systems. Together, our results provide an overview of the genetic mechanisms shaping the genomes of C. hyointestinalis subspecies, contributing to understand the biology of Campylobacter species that are increasingly recognized as emerging pathogens.
© 2021, The Author(s). MenosABSTRACT.
Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the under... Presentar Todo |
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Palabras claves : |
Computational biology and bioinformatics; Evolution; Microbiology. |
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Asunto categoría : |
A50 Investigación agraria |
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URL : |
https://www.nature.com/articles/s41598-021-82993-9.pdf
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Marc : |
LEADER 02962naa a2200265 a 4500
001 1061986
005 2021-04-15
008 2021 bl uuuu u00u1 u #d
022 $a2045-2322
024 7 $a10.1038/s41598-021-82993-9$2DOI
100 1 $aCOSTA, D.
245 $aPangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts.$h[electronic resource]
260 $c2021
500 $aArticle history: Received 12 February 2018; Accepted 24 January 2021; Published 09 February 2021.
520 $aABSTRACT. Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the underlying mechanism driving its diversification. Concordantly, both subspecies present distinct patterns of gene families involved in genome plasticity and DNA repair like CRISPR-associated proteins and restriction-modification systems. Together, our results provide an overview of the genetic mechanisms shaping the genomes of C. hyointestinalis subspecies, contributing to understand the biology of Campylobacter species that are increasingly recognized as emerging pathogens. © 2021, The Author(s).
653 $aComputational biology and bioinformatics
653 $aEvolution
653 $aMicrobiology
700 1 $aLÉVESQUE, S.
700 1 $aKUMAR, N.
700 1 $aFRESIA, P.
700 1 $aFERRÉS, I.
700 1 $aLAWLEY, T. D.
700 1 $aIRAOLA, G.
773 $tScientific Reports, 2021, Volume 11, Issue 1, Article number 3431. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-021-82993-9
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Registro original : |
INIA Las Brujas (LB) |
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| Registros recuperados : 30 | |
| 1. |  | FERRÉS, I.; FRESIA, P.; IRAOLA, G. simurg: simulate bacterial pangenomes in R. (Application note) Bioinformatics, 15 February 2020, Volume 36, Issue 4, Pages 1273-1274. Doi: https://doi.org/10.1093/bioinformatics/btz735 Article history: Received: 19 March 2019 / Revision received: 06 August 2019 / Accepted: 25 September 2019 / Published: 04 October 2019.
Corresponding author: Ferrés, I.; Microbial Genomics Laboratory, Institut Pasteur Montevideo,...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 3. | | BERNASCHINA, Y.; GARAYCOCHEA, S.; FRESIA, P.; LEONI, C. Efecto del manejo de suelo en la salud del viñedo. In: Sociedad Uruguaya de Fitopatología Jornada Uruguaya de Fitopatología, 6., Jornada Uruguaya de Protección Vegetal, 4., 21-22 octubre, 2021, Montevideo, Uruguay. Libro de resúmenes. Montevideo (UY): Sociedad Uruguay de Fitopatología (SUFIT), 2021. p. 27. Financiamiento: INIA - Proyecto INIA FR22: Respuesta fisiológica de frutales al estrés biótico y abiótico; componente 1: Respuestas fisiológicas de la vid al estrés hídrico y estrés biótico (Botrytis cinerea).| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Treinta y Tres. |
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| 4. | | VILLAR, A.; FRESIA, P.; CENTURIÓN, C.; TAVARES, E.; ABREO, E. P41. Comunidad microbiana asociada a clones de Eucalyptus dunnii y su efecto en el enraizamiento y sanidad de las estacas en vivero. [Poster]. Posters. In: Sociedad Uruguaya de Fitopatología (SUFIT). Jornada Uruguaya de Fitopatología, 7., Jornada Uruguaya de Protección Vegetal, 5., 10 noviembre 2023, Montevideo, Uruguay. Libro de resúmenes. 30 años SUFIT, 1993-2023. Montevideo (UY): Sociedad Uruguay de Fitopatología (SUFIT), 2023. p. 67. Financiamiento: UPM Biofore Uruguay; Instituto Nacional de Investigación Agropecuaria. -- Autor correspondencia: E-mail: avillar@inia.org.uy| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 7. | | BERGAMO, L.W.; SILVA-BRANDÃO, K.L.; VICENTINI, R.; FRESIA, P.; AZEREDO-ESPIN, A.M.L Genetic differentiation of a new world screwworm fly population from uruguay detected by snps, mitochondrial dna and microsatellites in two consecutive years. Insects, August 2020, Volume 11, Issue 8, Pages 1-16, Article number 539. OPEN ACCESS. DOI: https://doi.org/10.3390/insects11080539 Article history: Received 9 July 2020; Revised 2 August 2020; Accepted 9 August 2020; Published 16 August 2020.
This article belongs to the Special Issue Population Genetics of Insects -...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 8. | | NOVAS, R.; BASIKA, T.; WILLIAMSON, M. E.; FRESIA, P.; MENCHACA, A.; SCOTT, M. J. Identification and functional analysis of Cochliomyia hominivorax U6 gene promoters. Insect Molecular Biology, 2023. Early View. https://doi.org/10.1111/imb.12875 -- OPEN ACCESS. Article history: Received 9 March 2023, Accepted 4 August 2023, First published 21 September 2023. -- Scott, M.J.; Department of Entomology and Plant Pathology, North Carolina State University, Campus Box 7613, Raleigh, NC, United...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 9. | | KAVANOVÁ, M.; GARCIA, A.; FRESIA, P.; CONDON, F.; KASPARY, T. E.; CASTILLO, A.; DO CANTO, J. Múltiples orígenes de la resistencia a glifosato en las poblaciones de raigrás anual en la región. In: Sociedad Uruguaya de Fitopatología Jornada Uruguaya de Fitopatología, 6., Jornada Uruguaya de Protección Vegetal, 4., 21-22 octubre, 2021, Montevideo, Uruguay. Libro de resúmenes. Montevideo (UY): Sociedad Uruguay de Fitopatología (SUFIT), 2021. p. 80 Financiamiento: Agencia Nacional de Investigación e Innovación (FMV_3_2018_1_148682)| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Treinta y Tres. |
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| 10. | | DO CANTO, J.; KAVANOVÁ, M.; GARCIA, A.; FRESIA, P.; KASPARY, T. E.; CONDON, F.; CASTILLO, A. Resistencia a glifosato en raigrás anual en Uruguay. ¿La importamos o la generamos en el país? Revista INIA Uruguay, Setiembre 2021, no.66, p. 95-98. (Revista INIA; 66).| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA Treinta y Tres. |
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| 13. | | COSTA, D.; LÉVESQUE, S.; KUMAR, N.; FRESIA, P.; FERRÉS, I.; LAWLEY, T. D.; IRAOLA, G. Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts. Scientific Reports, 2021, Volume 11, Issue 1, Article number 3431. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-021-82993-9 Article history: Received 12 February 2018; Accepted 24 January 2021; Published 09 February 2021.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 14. | | TORRES, P.; ALTIER, N.; BEYHAUT, E.; FRESIA, P.; GARAYCOCHEA, S.; ABREO, E. Phenotypic, genomic and in planta characterization of Bacillus sensu lato for their phosphorus biofertilization and plant growth promotion features in soybean. Microbiological Research, 2024, Volume 280, e127566. https://doi.org/10.1016/j.micres.2023.127566 Article history: Received 12 November 2023; Received in revised form 30 November 2023; Accepted 2 December 2023; Available online 6 December 2023. -- Correspondence: Abreo, E.; Estación Experimental Wilson Ferreira Aldunate, Ruta 48 km...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 16. | | CABRERA, A.; PITA, S.; GONZÁLEZ, T.; VIERA, A.; VERGER, L.; PIEGAS, S.; WILLAT, G.; FRESIA, P.; BASMADJIÁN, Y. Genetic variability highlights the invasion route of the Lutzomyia longipalpis complex, the main vector of Visceral Leishmaniasis in Uruguay. Zoonoses and Public Health. 2023, Volume 70, Issue 5, Pages 383-392. doi: https://doi.org/10.1111/zph.13036 Article history: First published 10 March 2023. -- Correspondence author: Andrés, C.; Departamento de Parasitología y Micología, Instituto de Higiene, Facultad de Medicina, UdelaR, Montevideo, Uruguay; email:andresmcc1@gmail.com --...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 17. | | ETCHEVERS, I.; IRIARTE, M.V.; MARQUES, L.; FERENCZI, A.; DALLA RIZZA, M.; MARZAROLI, J.; SARAVIA, A.; FRESIA, P. Review on ecological interactions of the Cochliomyia hominivorax fly and assessment of the possible impacts of its eradication in Uruguay. [Revisión de las interacciones ecológicas de la mosca Cochliomyia hominivorax y evaluación de los posibles impactos ecológicos de su erradicación en Uruguay]. [Revisão das interações ecológicas da mosca Cochliomyia hominivorax e avaliação dos possíveis impactos ecológicos de sua erradicação no Uruguai]. Review. Agrociencia Uruguay, 2022, Vol.26, number 2, e1056. https://doi.org/10.31285/AGRO.26.1056 -- OPEN ACCESS. Article history: Received 12 May 2022; Accepted 19 Jul 2022; Published 16 Sep 2022. -- Correspondence: Ismael Etchevers, ismaelec@gmail.com ; Pablo Fresia,
pfresia@pasteur.edu.uy -- Editor: Milka Ferrer, Universidad de la República,...| Tipo: Artículos en Revistas Indexadas Nacionales | Circulación / Nivel : Nacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 18. | | DO CANTO, J.; KAVANOVÁ, M.; GARCÍA, M.A.; DE AVILA, A.; FRESIA, P.; TUESCA, D.H.; CONDON, F.; GAINES, T. Proyecto: Resistencia a glifosato en raigrás anual en Uruguay-entender, reducir y prevenir- [Poster]. In: Encuentro Latinoamericano y del Caribe de Biotecnología Agropecuaria; Simposio RedBio Argentina, 11., Montevideo 12-15 noviembre, 2019. Serie Técnica 253: Libro de Resúmenes.| Biblioteca(s): INIA Tacuarembó. |
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| 19. | | CERECETTO, V.; SMALLA , K.; NESME, J; GARAYCOCHEA, S.; FRESIA, P.; SØRENSEN, S.J.; BABIN, D.; LEONI, C. Reduced tillage, cover crops and organic amendments affect soil microbiota and improve soil health in Uruguayan vegetable farming systems. FEMS Microbiology Ecology, March 2021, Volume 97, Issue 3, fiab023. Doi: https://doi.org/10.1093/femsec/fiab023 Article history: Received 05 August 2020; Accepted 04 February 2021; Published 06 February 2021.
Editor: Angela Sessitsch.
This work was supported by Instituto Nacional de Investigación Agropecuaria, Uruguay (Project INIA SA35 - Effect of...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 20. | | VASINI, B.; FARACE, P.; ARIEL, A.; CIRONE, K.; MÉNDEZ, L.; MORSELLA, C.; FRESIA, P.; IRAOLA, G.; GIOFFRÉ, A.; PAOLICCHI, F. Phylogenetic and multiple-locus variable number tandem repeat analysis of Mycobacterium avium subsp. paratuberculosis isolates from Argentina. Veterinary Research Communications, December 2022, Volume 46, Issue 4, pages 1121-1129. doi: https://doi.org/10.1007/s11259-022-09983-8 Article history: Received 24 February 2022; Accepted 3 August 2022. -- Corresponding author: Vasini, B.; Laboratorio de Bacteriología-Grupo de Sanidad Animal, Unidad Integrada INTA-Universidad Nacional de Mar del Plata-Balcarce, Buenos...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| Registros recuperados : 30 | |
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